Substance adapted to lab use by Fanny Hesse in 1881

Published by Naitik Mehta · June 1, 2025

Stuck on the clue Substance adapted to lab use by Fanny Hesse in 1881 from the New York Times Daily for June 1, 2025? We have the correct 4-letter answer, including the definition, alternative hints, as well as other answers from the same crossword. Ready to learn more about this clue?

Clue

Substance adapted to lab use by Fanny Hesse in 1881 (4)

Answer

A
G
A
R

The answer to Substance adapted to lab use by Fanny Hesse in 1881 is Agar (4 letters).

Why does Agar fit this clue?

This clue works as a historical direct definition, naming the answer AGAR through a specific scientific milestone. Agar is a gelatinous substance derived from red algae that solidifies at room temperature and is used as a growth medium in microbiology labs. Fanny Hesse, a lab assistant working alongside her husband Walther Hesse in Robert Koch's laboratory, suggested using agar as a replacement for gelatin in petri dishes because it stays firm at body temperature and resists bacterial breakdown. Her 1881 adaptation transformed lab culture work and made agar a cornerstone of microbiology.

What does Substance adapted to lab use by Fanny Hesse in 1881 mean?

We break down each word in the clue and show its dictionary definitions below.

substance

noun

•a particular kind of matter with uniform properties

adapted

verb

•modified or adjusted for a particular use or purpose

lab

noun

•short for laboratory, a room for scientific experiments

Fanny Hesse

proper noun

•wife of microbiologist Walther Hesse who suggested using agar-agar as a solidifying agent for bacterial culture media

Where did this clue appear?

This clue appeared as 44-across in the New York Times Daily on June 1, 2025, by Sam Brody, edited by Will Shortz. See all answers for this puzzle.

Read the NYT Wordplay column for this puzzle.

NYT Daily — Jun 1, 2025

Get help on the whole puzzle

What does Agar mean?

noun

•A gelatinous material obtained from red algae, especially Gracilaria species, used as a bacterial culture medium, in electrophoresis and as a food additive.

•A culture medium based on this material.

Origin of the word Agar

•origin: Malay 'agar-agar'

•period: 19th century

The word entered English through scientific terminology when European botanists discovered this seaweed-derived gel substance used in Asian cuisine and later adopted it as a crucial medium for bacterial cultures in laboratories.

How to use Agar in a sentence

Here are 3 examples of how to use the word Agar.

•“Fanny Hesse suggested using agar as a solidifying agent for bacterial culture media in 1881, revolutionizing microbiology laboratory techniques.”

•“The scientist prepared petri dishes with nutrient agar to grow bacterial colonies for her research on antibiotic resistance.”

•“Many Asian desserts use agar as a vegan alternative to gelatin because it sets at room temperature and creates a firm, translucent texture.”

What are other crossword clues for Agar?

Learn about related clues

All clues from the New York Times Daily, Jun 1, 2025 crossword

The New York Times Daily for June 1, 2025 titled “Making Arrangements” was published by Sam Brody and has 140 clues. Curious about all the answers from this crossword puzzle? View all answers here.

Across

1AWarm shade of brown (5)6AOtherwise (4)10APlace (5)15A"In that case …" (4)19AWarm shade of white (5)20ALeader of the world's smallest country (4)21AVice follower (5)22ACambodian cash (4)23ALEGAL NICETY (21)27AWhole lot (4)28A"___, so good!" (furniture store pun) (4)29AExample of industry in Proverbs 6:6-9 (3)30AThey might be ripe for changing (7)31APolish language (4)33ACamera inits. (3)35ACoerced (into) (7)37AMagicians' cries (5)39AEARTH (13)42ABridge support (5)43ASuffers the cost (4)44ASubstance adapted to lab use by Fanny Hesse in 1881 (4)45AGrow weary (4)47AKind of policy that encourages transparency from leadership (8)49A"OMG, enough!" (3)51ANorthwestern abode (4)54ARent (3)55AGLIBNESS (13)58AOne "M" of the M.M.R. vaccine (7)60AInflation meas. (3)61A"Paradise ___" (4)62APepsi, e.g. (4)64ABig Apple airport code (3)65AGuess (9)69AObvious choice (9)73AOrg. enabled by the 16th Amendment (3)74ASmell (4)76AOn (4)77ADarn, say (3)79AHome of Morehouse College (7)83ARESIST (13)87AOne may be fawning (3)88AEuropean capital through which the Akerselva flows (4)90AChill (3)91APod or husk, botanically (8)92AArmy NCO (4)94AWord after game or floor (4)96ASweden joined it in 2024 (4)98AConsumed (5)99ARAGES (13)103APeddled things (5)104AHawaiian song of farewell (7)105AMeas. roughly equivalent to 10 billion 12-Downs (3)106ABit of equipment for a vault (4)107ALayer (7)109ASurveillance org. (3)111ANerve (4)113AGive for free (4)117AROYAL PERMIT (21)121ANumber after zwei (4)122ACarbon copy (5)123AWeakness (4)124AConfident bearing (5)125A___ Lee (4)126ACut down (5)127AHot things, briefly (4)128AAdjust (5)

Down

1DUnlikely fliers, in a saying (4)2DFirst name in stunts (4)3DObstacle course element (4)4D"Is that all you have to tell me?" (9)5DBig Apple media inits. (3)6DPark known as a "permanent world's fair" (5)7DTake things easy (4)8DOstentatious (7)9D___ sauce (condiment also called nitsume) (3)10DNonspeaking character in "Frozen" (4)11DAid-de-camp? (7)12DPiece of work? (3)13DExcluding (9)14DBakery treat (6)15D"In case my message isn't landing …" (7)16DIt might begin with a false alarm (9)17DFortuneteller (4)18DEarly automaker (4)24DEgyptian fertility goddess (4)25DMuffler material, maybe (4)26DComfort (4)32DFantasy role-playing game, for short (5)34DEndures (5)36DWay out of town, perhaps (4)37DAuthor's assistant (6)38DLoss of the ability to read (6)39DIs so inclined (7)40DNarrow the gap with, competitively (6)41DBranching diagram (4)42DCeremony (4)43DSome collared shirts (5)46DFigures in some storied abductions, for short (3)48DRegional divisions in Russia (7)50DIt may be dropped for effect (3)52DLose progress, in a way (7)53DMembers of a priestly caste of ancient Persia (4)56DGerman town (5)57DRudely revel in victory, say (5)59DJapanese honorific (3)63DTwo-version marketing experiments (7)66DRio maker (3)67DPuzzlemaker Rubik (4)68DFiddler's skill (6)70DWyoming's Cheyenne Frontier Days, e.g. (5)71DWhat you will (6)72DBrand with cup sizes from "minis" to "world's largest" (6)75DRock's Ocasek (3)78DSmall songbird (4)79DOft-skipped podcast parts (3)80DFling (4)81DAccessory in a Jane Fonda workout video (9)82DHe's a head of the pack (9)84DFrench upper house (5)85DFaultless (5)86DFaux gardener, so to speak (9)89DButter substitute (4)93DPopular food fish or its genus name (7)95DFundamental building block of DNA (7)97DGreen often found in mixed greens (7)100DRevealer of "the man behind the curtain" (4)101DCenter of mass? (6)102DSite with a "Clothing, Shoes & Accessories" section (4)103DFairy tale villain (4)106DClears of snow, say (5)107DConventions: Abbr. (4)108DTrillion: Prefix (4)110DRunner on runners (4)112DSomewhat (4)114DSlobbery cartoon pet (4)115DArizona's third-largest city (4)116DEarly education option, for short (4)118DDesirable formation for ducks (3)119DAwry (3)120DElect (3)

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Frequently asked questions about Substance adapted to lab use by Fanny Hesse in 1881

What is the answer to Substance adapted to lab use by Fanny Hesse in 1881?
The answer is Agar (4 letters).
Where did this clue appear?
This clue was last seen in the New York Times Daily on June 1, 2025.
How many letters does the answer to Substance adapted to lab use by Fanny Hesse in 1881 have?
The answer has 4 letters: Agar.

Author

Naitik Mehta

Naitik Mehta

Co-founder

Naitik is a gaming enthusiast who loves solving daily word games and enjoys the friendly competition from time to time. He is the co-founder of Crossword Chef and enjoys thinking about how to make crossword solving more fun for everyone around the world.